BRAIN - Pneumococcal meningitis

The brain is that of an infant; it shows very prominent congested superficial vessels with a thick exudate covering much of the cortex.
This child presented at the age of three months with a one-week history of irritability and crying. A lumbar puncture grew S. pneumoniae; there was no response to therapy and the child died three days after admission. The child suffered Down's syndrome and at autopsy congenital atrial septal defect was demonstrated. Histological examination of tissues showed evidence of a terminal disseminated intravascular coagulation.