BRAIN - Microcephaly

The specimen is a whole brain. The cerebellum and occipital lobes appear unremarkable. There is hypoplasia of the temporal lobes and the inferior portions of the frontal lobes. There is aplasia of the parietal lobes and the superior part of the frontal lobes. The ventricular system is dilated and there is direct communication between the lateral ventricles and the subarachnoid space.
The patient was a 7 year old female who was delivered following a normal pregnancy. There was no chromosomal abnormality. The patient had a spastic quadraplegia, with severe mental retardation and grand mal epilepsy