SKULL, CLAVICLE - Neuroblastoma

This shows two portions of skull and one clavicle cut longitudinally. The skull shows haemorrhagic tumour, both on the outer aspect and on the inner aspect. The tumour is roughly nodular and tumour tissue is present between the tables. In the clavicle, the tumour is less well defined, but is extending through much of the length of the bone.
This young man presented at the age of 21 with a large pelvic tumour; this was retroperitoneal and obliterated the pelvic cavity displacing the left ureter and sigmoid colon. The tumour did not appear to be encapsulated, and numerous abnormal nerves were related to it. Removal was incomplete. The history was that of a partially differentiated ganglioneuroma. He continued to have pelvic pain; he developed intermittent haematuria and ultimately an aplastic anaemia and hyperglycaemia (? secondary to steriods). He required many transfusions, which he ultimately declined. At autopsy, five years after diagnosis, he showed a haemorrhagic tumour mass in the pelvis with obstruction of the left ureter; secondary deposits in liver, ribs, vertebral bodies, clavicles and skull and lung.